What is permanent in this world? What can give us lasting happiness? Everything is changing and all the happiness we have from the outside world is temporary. The real happiness comes from within. Chasing happiness outside is like scratching an itch.
You have an itch and so you feel like scratching it. You start scratching a little and you enjoy that. You scratch a little more, you enjoy a little more. Scratch more and more, ultimately it burns and you bleed. Worldly desires themselves are like an itch to a person of wisdom.
They begin and then you scratch. You will feel happiness. The more and more you scratch, ultimately you come into difficulty. That is how life goes on for the one without wisdom.